Depletion of Alloreactive T-Cells by Anti-CD137-Saporin Immunotoxin
Depletion of alloreactive T-lymphocytes from allogeneic bone marrow tansplants may prevent graft-versus-host disease (GVHD) without impairing donor cell engraftment, immunity, and the graft-versus-leukemia (GVL) effect.Alloreactive T-cells may be identified by their expression, upon activation, of CD137, a costimulatory receptor and putative surrog